Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns
Identifieur interne : 001115 ( Main/Exploration ); précédent : 001114; suivant : 001116Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns
Auteurs : Jaffar A. Al-Tawfiq [États-Unis] ; Ali S. Omrani ; Ziad A. MemishSource :
- Frontiers of Medicine [ 2095-0217 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- traitement médicamenteux : Infections à coronavirus.
- usage thérapeutique : Antiviraux.
- virologie : Infection croisée.
- épidémiologie : Infections à coronavirus.
- Coronavirus du syndrome respiratoire du Moyen-Orient, Flambées de maladies, Humains, Saisons, Voyage.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Antiviral Agents.
- drug therapy : Coronavirus Infections.
- epidemiology : Coronavirus Infections.
- virology : Cross Infection.
- Disease Outbreaks, Humans, Middle East Respiratory Syndrome Coronavirus, Seasons, Travel.
Abstract
The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 brought back memories of the occurrence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002. More than 1500 MERS-CoV cases were recorded in 42 months with a case fatality rate (CFR) of 40%. Meanwhile, 8000 cases of SARS-CoV were confirmed in six months with a CFR of 10%. The clinical presentation of MERS-CoV ranges from mild and non-specific presentation to progressive and severe pneumonia. No predictive signs or symptoms exist to differentiate MERS-CoV from community-acquired pneumonia in hospitalized patients. An apparent heterogeneity was observed in transmission. Most MERS-CoV cases were secondary to large outbreaks in healthcare settings. These cases were secondary to community-acquired cases, which may also cause family outbreaks. Travel-associated MERS infection remains low. However, the virus exhibited a clear tendency to cause large outbreaks outside the Arabian Peninsula as exemplified by the outbreak in the Republic of Korea. In this review, we summarize the current knowledge about MERS-CoV and highlight travel-related issues.
Url:
DOI: 10.1007/s11684-016-0446-y
PubMed: 27146399
PubMed Central: 7089395
Affiliations:
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Le document en format XML
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More than 1500 MERS-CoV cases were recorded in 42 months with a case fatality rate (CFR) of 40%. Meanwhile, 8000 cases of SARS-CoV were confirmed in six months with a CFR of 10%. The clinical presentation of MERS-CoV ranges from mild and non-specific presentation to progressive and severe pneumonia. No predictive signs or symptoms exist to differentiate MERS-CoV from community-acquired pneumonia in hospitalized patients. An apparent heterogeneity was observed in transmission. Most MERS-CoV cases were secondary to large outbreaks in healthcare settings. These cases were secondary to community-acquired cases, which may also cause family outbreaks. Travel-associated MERS infection remains low. However, the virus exhibited a clear tendency to cause large outbreaks outside the Arabian Peninsula as exemplified by the outbreak in the Republic of Korea. In this review, we summarize the current knowledge about MERS-CoV and highlight travel-related issues.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Zumla, A" uniqKey="Zumla A">A Zumla</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Zumla, A" uniqKey="Zumla A">A Zumla</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name></author><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM 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Qin</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Uj" uniqKey="Kim U">UJ Kim</name></author><author><name sortKey="Won, Ej" uniqKey="Won E">EJ Won</name></author><author><name sortKey="Kee, Sj" uniqKey="Kee S">SJ Kee</name></author><author><name sortKey="Jung, Si" uniqKey="Jung S">SI Jung</name></author><author><name sortKey="Jang, Hc" uniqKey="Jang H">HC Jang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Indiana</li></region></list><tree><noCountry><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name><name sortKey="Omrani, Ali S" sort="Omrani, Ali S" uniqKey="Omrani A" first="Ali S." last="Omrani">Ali S. Omrani</name></noCountry><country name="États-Unis"><region name="Indiana"><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A." last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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